Post-Doc fellowship in Mechanobiological characterization of vascular ageing conditions from molecular to tissue scales - 24 months fixed-term contract

Sur site
- SAINT ETIENNE, Auvergne-Rhône-Alpes, France
Ingénierie et services de la santé

Description de l'offre d'emploi

JOB ENVIRONMENT:

Mines Saint-Etienne (MSE), one of the graduate schools of Institut Mines Télécom, the #1 group of graduate schools of engineering and management in France under the supervision of the Ministry of the Economy, Industry and Digital Technology, is assigned missions of education, research and innovation, transfer to industry and scientific, technological and industrial culture.

MSE consists of 2,400 graduate and postgraduate students, 400 staff, a consolidated budget of €46M, three sites on the Saint-Etienne campus (Auvergne Rhone-Alpes region, Lyon Saint-Etienne metropolitan area), a campus in Gardanne (SUD region, Aix Marseille metropolitan area), a site in Lyon within the digital campus of Auvergne Rhone-Alpes Region, six research units, five teaching and research centres and one of the leading French science community centres (La Rotonde €1M budget and +40,000 visitors per year). The Times Higher Education World University Ranking ranked us for 2022 in the 251-300 range for Engineering and Technology. Our work environment is characterised by high Faculty-to-Student, Staff-to-Faculty and PhD-to-Faculty ratios, as well as comprehensive state-of-the-art experimental and computational facilities for research, teaching and transfer to industry.

Website: https://www.mines-stetienne.fr/

The CIS brings together 70 people, including 18 professors in engineering industrial/computing, biomechanics and healthcare engineering. Since its creation in 2004, the CIS has been representative of the ability of Mines Saint-Etienne to acquire leadership on innovative themes such as, for example,

Soft tissue biomechanics. SAINBIOSE (INSERM UMR 1059) brings together researchers from the CIS (biomechanics, biomaterials and bioengineering), the faculty of Medicine from Jean Monnet University, Saint-Etienne University Hospital, Inserm and the French Blood Establishment. The global scientific objective of SAINBIOSE is a better understanding and of biostress in osteoarticular (LBTO team) and cardiovascular pathology (DVH team).

Website: https://sainbiose-lab.fr/

Biomechanics, experimental and computational, is a major research topic of SAINBIOSE, which goes from modelling the mechanical behaviour of tissues to clinical and industrial applications, especially with the textile industry. In 2024, Prof Stéphane Avril was awarded an ERC Advanced grant from the European Research Council for the project JuvenTwin “Multiscale mechanobiological synergies in vascular homeostasis, ageing and rejuvenation”, which aims to establish multiscale digital twins of ageing effects on vascular mechanobiology and to simulate and screen effective rejuvenation treatments. This project will take place in a research group having 15 years experience in biomechanics and mechanobiology (https://emse.fr/~avril/).

JOB DESCRIPTION:

We open a non-permanent position of post-doctoral fellow to join the Avril’s team working on JuvenTwin’s project. The work will be carried out at Mines Saint-Etienne, within the SAINBIOSE research unit (Inserm U1059). It is based at the Centre Ingénierie et Santé (Hospital campus at the North of Saint-Etienne).

The main missions of the post-doctoral fellow will be to:

1: Perform functional studies on excised aortas such as mechanical tests with custom computer-controlled extension-distension testing device

2. Implement, adapt and coordinate molecular biology techniques such as spatial transcriptomics to analyse the excised aorta

3. Connect with the other work package of the project focusing on vascular smooth muscle cells and computational modelling

4. Apply for grant calls, results communication inside and outside the laboratory (European network, national and international conferences).

A stay of 6 months at Yale University (Jay Humphrey’s lab) is planned.

Pré-requis du poste

PROFIL SOUGHT:

The candidate should hold a PhD degree in biomechanics, mechanobiology, biochemistry, biophysics, or molecular biology and should satisfy the following criteria:

Good knowledge of basic cell biology and molecular biology tools
Familiarity with biomechanics techniques, first experience with testing blood vessels is a plus
Interest in innovation, technology development and translational research
Knowledge of written and spoken English is a requirement
Capacity to successfully integrate a team and a group within a R&D environment,
Rigor, methodology and organization, dynamism, autonomy and critical sense
Expertise in front-end and back-end development.

WHY JOIN US:

Institut Mines-Telecom is characterised by:

https://www.youtube.com/watch?v=m39m6hdNC48

A scientific environment of excellence
A group with entities throughout France

Mines Saint-Etienne is distinguished by:

A privileged working environment with a high student supervision rate and a high environment rate (support and back-up functions)
First-rate experimental and digital resources
Significant contract research activity (€11m/year in Research and Innovation contracts), mainly with industrial partners
25% international students, Member of the T.I.M.E. network and the EULIST European University
A centre for scientific, technical and industrial culture - La Rotonde - which is unique in France, and which has a major impact on society (> 50,000 visitors per year)
Pleasant workplace, easily accessible by public transport and close to motorways
Public transport costs reimbursed up to 75% (subject to conditions)
Sustainable mobility package
Staff committee that subsidises sports, leisure, cultural and social events and activities
The possibility of partial remote working
49 days annual leave

ADDITIONAL INFORMATION:

Recruitment conditions:

Fixed-term contract for a period of 24 months
Desired start date: 1st september 2025
Remuneration will be set according to the candidate's profile, based on the rules defined by the Institut Mines Télécom's management framework
Full time
Position based in Saint-Étienne
For internal use:
> Category II - Job P - Post doctorant according to the Management Framework

The position is open to all, with accommodation available on request for candidates with disabilities. The job is open to civil servants and/or the general public.
All applications may be subject to an administrative enquiry.

How to apply:

Applications (CV, covering letter, letter of recommendation if applicable) must be submitted on the RECRUITEE platform no later than 15/06/2025.

https://institutminestelecom.recruitee.com/o/post-doc-position-mechanobiological-characterization-of-vascular-ageing-conditions-from-molecular-to-tissue-scales

Candidates selected for an interview will be informed rapidly. Part of the interview will be held in English.

As part of its Equality, Diversity and Inclusion policy, École des Mines de Saint Etienne is an employer that is committed to fair treatment of all applicants.

For more information:

For further information about the position, please contact:

Stephane AVRIL – Researcher

avril@emse.fr

04 77 42 01 88

For all administrative information, please contact:

Milica PETKOVIC – Human Resources

Phone + 33 (0)4 77 42 02 08

milica.petkovic@emse.fr

Useful links:

https://www.mines-stetienne.fr/

https://www.imt.fr/